Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0281 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0175 | 0.4774 | 0.2515 |
Loa Loa (eye worm) | carboxylesterase | 0.0281 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.3019 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0635 | 0.0635 |
Brugia malayi | hypothetical protein | 0.0091 | 0.0635 | 0.0635 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4774 | 0.442 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4774 | 0.442 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0139 | 0.3019 | 0.3019 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0635 | 0.0635 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0084 | 0.0292 | 1 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.3019 | 0.2546 |
Echinococcus multilocularis | acetylcholinesterase | 0.0281 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0175 | 0.4774 | 0.2515 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.3019 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0281 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0281 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0281 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0281 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0292 | 0.0969 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0292 | 0.0969 |
Brugia malayi | Heterochromatin protein 1 | 0.0139 | 0.3019 | 0.3019 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.7122 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0281 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.3019 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.7 uM | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as concentration required to obtain F-luciferase expression/R-luciferase expression ratio 3 | ChEMBL. | 24261904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.