Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0243 | 0.192 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0439 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0439 | 1 | 0.5 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0439 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.62 ug ml-1 | Binding affinity against PBP2a receptor by competition analysis with [3H]-benzylpenicillin using cell membrane fractions from the MRSA COL strain. | ChEMBL. | 10576693 |
MIC50 (functional) | = 2 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) | ChEMBL. | 10576693 |
MIC50 (functional) | = 4 ug ml-1 | Antibacterial activity against methicillin-resistant coagulase negative Staphylococci (MRCNS) | ChEMBL. | 10576693 |
MIC90 (functional) | = 4 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) | ChEMBL. | 10576693 |
MIC90 (functional) | = 8 ug ml-1 | Antibacterial activity against methicillin-resistant coagulase negative Staphylococci (MRCNS) | ChEMBL. | 10576693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.