Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 500 ug ml-1 | Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay | ChEMBL. | 24480358 |
MIC (functional) | = 250 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 22019 after 18 to 24 hrs by microbroth dilution method | ChEMBL. | 24480358 |
MIC (functional) | = 250 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by microbroth dilution method | ChEMBL. | 24480358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.