Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6.4 % | Induction of apoptosis in mouse B16F10 cells assessed as necrotic cells at 2 X IC50 after 72 hrs by annexin V-FITC/propidium iodide staining-based FACS analysis (Rvb = 4.0 +/- 0.6%) | ChEMBL. | 24480359 |
IC50 (functional) | = 14.2 uM | Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay | ChEMBL. | 24480359 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 24480359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.