Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0108 | 1 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0108 | 1 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0108 | 1 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0108 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0068 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0108 | 1 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0108 | 1 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0108 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0108 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of HIF-1alpha in human MDA-MB-231 cells at 10 uM after 18 hrs by Western blotting analysis in hypoxia condition | ChEMBL. | 24485121 | |
Inhibition (binding) | Inhibition of Stat3 phosphorylation in human MDA-MB-231 cells assessed as inhibition of c-Myc expression at 1 to 20 uM by Western blotting analysis | ChEMBL. | 24485121 | |
Inhibition (binding) | Inhibition of Stat3 phosphorylation in human MDA-MB-231 cells at 1 to 20 uM by Western blotting analysis | ChEMBL. | 24485121 | |
Inhibition (binding) | Inhibition of Stat3 in human MDA-MB-231 cells assessed as inhibition of Stat3 phosphorylation at 10 uM after 18 hrs by Western blotting analysis | ChEMBL. | 24485121 | |
Inhibition (binding) | Inhibition of HIF-1 alpha in human MDA-MB-231 cells at 1 to 20 uM by Western blotting analysis | ChEMBL. | 24485121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.