Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.78 ug ml-1 | Inhibitory concentration required against A 431 human epidermoid carcinoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 0.78 ug ml-1 | Inhibitory concentration required against A 431 human epidermoid carcinoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 0.91 ug ml-1 | Inhibitory concentration of the compound required against LOX-IMVI melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 0.9100000000000001 ug ml-1 | Inhibitory concentration of the compound required against LOX-IMVI melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 1.47 ug ml-1 | Inhibitory concentration of the compound required against SW620 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 1.47 ug ml-1 | Inhibitory concentration of the compound required against SW620 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 1.58 ug ml-1 | Inhibitory concentration of the compound required against HCT 15 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 1.58 ug ml-1 | Inhibitory concentration of the compound required against HCT 15 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 2.16 ug ml-1 | Inhibitory concentration of the compound required against HT 29 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 2.16 ug ml-1 | Inhibitory concentration of the compound required against HT 29 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 2.49 ug ml-1 | Inhibitory concentration of the compound required against SNB19 CNS cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 2.49 ug ml-1 | Inhibitory concentration of the compound required against SNB19 CNS cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.19 ug ml-1 | Inhibitory concentration of the compound required against ACHN renal cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.19 ug ml-1 | Inhibitory concentration of the compound required against ACHN renal cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.28 ug ml-1 | Inhibitory concentration of the compound required against DLD-1 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.28 ug ml-1 | Inhibitory concentration of the compound required against DLD-1 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against COLO 205 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against UACC62 melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against MDA-MB-231 breast cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against COLO 205 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against UACC62 melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 3.69 ug ml-1 | Inhibitory concentration of the compound required against MDA-MB-231 breast cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.59 ug ml-1 | Inhibitory concentration of the compound required against HCC-2998 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.59 ug ml-1 | Inhibitory concentration of the compound required against HCC-2998 colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.69 ug ml-1 | Inhibitory concentration of the compound required against MCF-7 breast cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.69 ug ml-1 | Inhibitory concentration of the compound required against MCF-7 breast cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.78 ug ml-1 | Inhibitory concentration of the compound required against A 549 lung cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 4.78 ug ml-1 | Inhibitory concentration of the compound required against A 549 lung cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 5.16 ug ml-1 | Inhibitory concentration of the compound required against NCI-H23 lung cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 5.16 ug ml-1 | Inhibitory concentration of the compound required against NCI-H23 lung cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 5.67 ug ml-1 | Inhibitory concentration of the compound required against PC-3 prostate cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 5.67 ug ml-1 | Inhibitory concentration of the compound required against PC-3 prostate cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 7.16 ug ml-1 | Inhibitory concentration against B16 murine melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 7.16 ug ml-1 | Inhibitory concentration against B16 murine melanoma cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 9.03 ug ml-1 | Inhibitory concentration against HCT 116 human colon cancer cell line | ChEMBL. | 11354370 |
IC50 (functional) | = 9.030000000000001 ug ml-1 | Inhibitory concentration against HCT 116 human colon cancer cell line | ChEMBL. | 11354370 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 11354370 | |
Homo sapiens | ChEMBL23 | 11354370 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.