Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.2831 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.2831 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.2595 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.2831 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 5 ml/min.kg | Clearance in human hepatocytes at 0.5 uM after 120 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
F (ADMET) | = 12 % | Oral bioavailability in CD-1 mouse at 5 mg/kg by LC/MS/MS analysis | ChEMBL. | 23544424 |
IC50 (ADMET) | > 20 uM | Inhibition of CYP2D6 in human liver microsomes after 10 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
IC50 (ADMET) | > 20 uM | Inhibition of CYP2C19 in human liver microsomes after 10 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
IC50 (ADMET) | > 20 uM | Inhibition of CYP2C9 in human liver microsomes after 10 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
IC50 (ADMET) | > 20 uM | Inhibition of CYP1A2 in human liver microsomes after 10 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
IC50 (ADMET) | > 20 uM | Inhibition of CYP3A4 in human liver microsomes after 7 mins by LC/MS/MS analysis | ChEMBL. | 23544424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.