Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 10A | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Trypanosoma brucei | cAMP-specific phosphodiesterase | phosphodiesterase 10A | 789 aa | 666 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0664 | 1 | 0.5 | |
Echinococcus granulosus | Transglutaminase | 0.0664 | 1 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0664 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0664 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0664 | 1 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0664 | 1 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0664 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0664 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0664 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0577 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0664 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0664 | 1 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0664 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 305 nM | Inhibition of human recombinant full length PDE10A2 expressed in SF9 cells infected with baculovirus expression system using cAMP as substrate incubated 30 mins prior to substrate addition measured after 60 mins by HTRF method | ChEMBL. | 24238902 |
IC50 (ADMET) | = 0.63 uM | Inhibition of CYP1A2 (unknown origin) after 20 mins by fluorescence assay | ChEMBL. | 24238902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.