Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | mitochondrial cardiolipin synthase, putative | 0.0175 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.1091 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0206 | 0.034 | 0.034 |
Plasmodium vivax | phosphatidylglycerophosphate synthase, putative | 0.0175 | 0 | 0.5 |
Onchocerca volvulus | Putative phospholipase D | 0.0206 | 0.034 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.1091 | 1 | 1 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0175 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 0.5848 | 0.7225 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0175 | 0 | 0.5 |
Loa Loa (eye worm) | phospholipase D | 0.0206 | 0.034 | 0.042 |
Schistosoma mansoni | phospholipase D | 0.1091 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.038 | 0.2246 | 0.2246 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0175 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0916 | 0.8094 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.038 | 0.2246 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.038 | 0.2246 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.1091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0916 | 0.8094 | 1 |
Echinococcus granulosus | phospholipase D1 | 0.1091 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0963 | 0.8611 | 0.8562 |
Plasmodium falciparum | phosphatidylglycerophosphate synthase | 0.0175 | 0 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.038 | 0.2246 | 1 |
Plasmodium vivax | cardiolipin synthetase, putative | 0.0175 | 0 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.038 | 0.2246 | 0.5 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.038 | 0.2246 | 0.5 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0175 | 0 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.0963 | 0.8611 | 0.8562 |
Wolbachia endosymbiont of Brugia malayi | cardiolipin synthase | 0.0175 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.034 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 0.5848 | 0.7225 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0175 | 0 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0175 | 0 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0206 | 0.034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 32 % | Inhibition of apomorphine-induced aggression in male rats after intraperitoneal administration of 25 mg/kg of compound | ChEMBL. | 9379440 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.