Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0159 | 1 |
Trichomonas vaginalis | sensor histidine kinase, putative | 0.0019 | 0.0386 | 1 |
Mycobacterium leprae | PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 | 0.0015 | 0.0183 | 0.0342 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0019 | 0.0386 | 1 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0095 | 0.3837 | 0.5 |
Mycobacterium tuberculosis | Two component sensor histidine kinase TrcS | 0.0015 | 0.0183 | 0.0562 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0013 | 0.0074 | 0.5 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0159 | 1 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0019 | 0.0386 | 1 |
Mycobacterium tuberculosis | Two component sensory transduction histidine kinase MtrB | 0.0015 | 0.0183 | 0.0562 |
Mycobacterium tuberculosis | Possible two component sensor kinase TcrY | 0.0015 | 0.0183 | 0.0562 |
Trichomonas vaginalis | two component sensor and regulator histidine kinase bacteria, putative | 0.0019 | 0.0386 | 1 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0082 | 0.3255 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0159 | 1 |
Mycobacterium leprae | TWO COMPONENT SENSOR HISTIDINE KINASE PRRB | 0.0082 | 0.3255 | 1 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0159 | 1 |
Trichomonas vaginalis | sensory transduction histidine kinase, putative | 0.0019 | 0.0386 | 1 |
Brugia malayi | PAS domain containing protein | 0.0013 | 0.0074 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0074 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0229 | 0.9996 | 0.9996 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0074 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.0074 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0229 | 1 | 1 |
Mycobacterium tuberculosis | Two component sensor kinase MprB | 0.0015 | 0.0183 | 0.0562 |
Mycobacterium tuberculosis | Probable sensor protein KdpD | 0.0015 | 0.0183 | 0.0562 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0159 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0229 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0074 | 0.5 |
Mycobacterium leprae | Probable two component sensor kinase MprB | 0.0015 | 0.0183 | 0.0342 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0229 | 0.9996 | 0.9996 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0082 | 0.3255 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0229 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0229 | 1 | 0.5 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0019 | 0.0386 | 1 |
Mycobacterium tuberculosis | Possible two component system response sensor kinase membrane associated PhoR | 0.0015 | 0.0183 | 0.0562 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0082 | 0.3255 | 1 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0019 | 0.0386 | 1 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0019 | 0.0386 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24565905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.