Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | anaplastic lymphoma receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | TK/ALK protein kinase | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.6715 | 0.6418 |
Loa Loa (eye worm) | TTK protein kinase | 0.0371 | 1 | 1 |
Echinococcus granulosus | MAM | 0.0034 | 0.0828 | 0.0828 |
Trypanosoma brucei | protein kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0371 | 1 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0371 | 1 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0371 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0828 | 0.0828 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0371 | 1 | 0.5 |
Plasmodium falciparum | protein kinase, putative | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0828 | 0.0828 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0371 | 1 | 0.5 |
Echinococcus multilocularis | MAM | 0.0034 | 0.0828 | 0.0828 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0285 | 0.7677 | 0.7467 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0371 | 1 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0004 | 0 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.768 | 0.747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL/F (ADMET) | = 17 ml/min.kg | Apparent total intrinsic clearance in human liver microsomes | ChEMBL. | 24432909 |
Ki (binding) | = 7.5 nM | Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to Km levels of ATP addition measured after 1 hr by microfluidic mobility shift assay | ChEMBL. | 24432909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.