Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 30 mins by UV-vis spectrophotometry | ChEMBL. | 24247003 | |
IC50 (binding) | = 6.559 uM | Inhibition of gelatinase A (unknown origin) after 30 mins by spectrophotometry | ChEMBL. | 24247003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.