Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against multi-resistant Escherichia coli C/16702 after 24 hrs | ChEMBL. | 24397620 | |
Activity (functional) | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 24397620 | |
Activity (functional) | Antibacterial activity against Escherichia coli CCM 3954 after 24 hrs | ChEMBL. | 24397620 | |
CC50 (ADMET) | > 44 uM | Cytotoxicity against human HuH7 cells infected with Hepatitis C virus subtype 2a | ChEMBL. | 24397620 |
IC50 (functional) | = 5.73 uM | Antiproliferative activity against human HL60 cells after 72 hrs by XTT assay | ChEMBL. | 24397620 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24397620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.