Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5622 | 0.6164 |
Echinococcus granulosus | geminin | 0.019 | 0.5622 | 0.5622 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0248 | 0.7838 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0121 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0064 | 0.088 | 0.088 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5622 | 0.6164 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0283 | 0.912 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0064 | 0.088 | 0.1122 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0208 | 0.6319 | 0.6929 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0208 | 0.6319 | 0.6319 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0208 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0064 | 0.088 | 0.088 |
Echinococcus multilocularis | geminin | 0.019 | 0.5622 | 0.5622 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.8174 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0248 | 0.7838 | 0.7838 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0098 | 0.2162 | 0.2162 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0121 | 0.3042 | 0.3335 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.088 | 0.088 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0225 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 28136 nM | Antiplasmodial activity against multidrug sensitive Plasmodium falciparum NF54 assessed as parasite growth inhibition | ChEMBL. | 24099149 |
IC50 (functional) | > 28136 nM | Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 assessed as parasite growth inhibition | ChEMBL. | 24099149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.