Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1376 | 0.1222 | 0.0601 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.2173 | 0.1994 | 0.1427 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.1376 | 0.1222 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | tyrosine kinase | 0.0797 | 0.0661 | 0.0716 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.1376 | 0.1222 | 1 |
Leishmania major | extracellular receptor, putative | 0.0797 | 0.0661 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0797 | 0.0661 | 0.0661 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | hypothetical protein | 0.1376 | 0.1222 | 0.1324 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.7102 | 0.6769 | 0.7335 |
Loa Loa (eye worm) | glutamate receptor | 0.8478 | 0.8102 | 0.7968 |
Echinococcus multilocularis | tyrosine kinase | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | microtubule associated protein 2 | 0.2477 | 0.2288 | 0.2288 |
Schistosoma mansoni | thyroid hormone receptor | 0.0124 | 0.0009 | 0.001 |
Loa Loa (eye worm) | glutamate receptor | 0.3335 | 0.312 | 0.2633 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 1.0437 | 1 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.2173 | 0.1994 | 0.1792 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.4132 | 0.3892 | 0.4342 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0797 | 0.0661 | 0.0661 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.1376 | 0.1222 | 0.0754 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.964 | 0.9228 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.1376 | 0.1222 | 0.1222 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0797 | 0.0661 | 0.0661 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0797 | 0.0661 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0797 | 0.0661 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.8478 | 0.8102 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.7102 | 0.6769 | 0.6769 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0797 | 0.0661 | 0.0716 |
Echinococcus granulosus | glutamate receptor 2 | 0.0797 | 0.0661 | 0.0661 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.2173 | 0.1994 | 0.1427 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2477 | 0.2288 | 0.248 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | glutamate receptor 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.7102 | 0.6769 | 0.6769 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | protein kinase | 0.0797 | 0.0661 | 0.0716 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | tyrosine kinase | 0.0797 | 0.0661 | 0.0716 |
Echinococcus granulosus | tumor protein p63 | 0.0287 | 0.0166 | 0.0166 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.7681 | 0.733 | 0.8962 |
Loa Loa (eye worm) | hypothetical protein | 1.0437 | 1 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.1376 | 0.1222 | 0.1222 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus multilocularis | tumor protein p63 | 0.0287 | 0.0166 | 0.0166 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2477 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.2173 | 0.1994 | 0.1427 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0797 | 0.0661 | 0.0661 |
Schistosoma mansoni | thyroid hormone receptor | 0.0124 | 0.0009 | 0.001 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.4132 | 0.3892 | 0.4218 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0797 | 0.0661 | 0.0661 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0124 | 0.0009 | 0.0009 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 46 uM | Inhibition of 6x-His-tagged TNKS1 (unknown origin) after 60 mins | ChEMBL. | 24294969 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.