Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Xanthine dehydrogenase/oxidase | Starlite/ChEMBL | References |
Homo sapiens | xanthine dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | aldehyde oxidase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0141 | 0.1813 | 0.5229 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0418 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0197 | 0.3468 | 0.5951 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0197 | 0.3468 | 0.5951 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0197 | 0.3468 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0141 | 0.1813 | 0.3111 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0124 | 0.1304 | 0.2238 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0141 | 0.1813 | 0.3111 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0418 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0277 | 0.5827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.1 | Inhibition of rat xanthine oxidase | ChEMBL. | 24508129 |
IC50 (binding) | = 9 | Inhibition of C-terminally FLAG-tagged human xanthine oxidase (amino acid 1 to 1333) expressed in baculovirus system after 15 mins by spectrophotometry | ChEMBL. | 24508129 |
Papp (ADMET) | = 74 ucm/s | Apparent permeability across basolateral side to apical side in human Caco2 cells | ChEMBL. | 24508129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.