Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0854 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0854 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0854 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0854 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0854 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0854 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0854 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0854 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0854 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0854 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0854 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0854 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.3 M | Concentration required to relax phenylephrine-precontracted aortic rings by 50% in endothelium denuded rabbit aorta | ChEMBL. | 9703467 |
ED50 (functional) | = 5.4 M | Concentration required to relax phenylephrine-precontracted aortic rings by 50% in endothelium intact rat aorta | ChEMBL. | 9703467 |
Ki (binding) | = 5.5 | Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat submandibulary gland | ChEMBL. | 9703467 |
Ki (binding) | = 5.8 | Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat heart | ChEMBL. | 9703467 |
Ki (binding) | = 7 | Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]-pirenzepine from rat cerebral cortex | ChEMBL. | 9703467 |
Log Ki (binding) | = 5.5 | Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat submandibulary gland | ChEMBL. | 9703467 |
Log Ki (binding) | = 5.8 | Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat heart | ChEMBL. | 9703467 |
Log Ki (binding) | = 7 | Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]-pirenzepine from rat cerebral cortex | ChEMBL. | 9703467 |
Selectivity ratio (binding) | = 1.8 | Inhibitory selectivity for Muscarinic receptors M3 and M2 | ChEMBL. | 9703467 |
Selectivity ratio (binding) | = 16 | Inhibitory selectivity for Muscarinic receptors M2 and M1 | ChEMBL. | 9703467 |
Selectivity ratio (binding) | = 29 | Inhibitory selectivity for Muscarinic receptors M3 and M1 | ChEMBL. | 9703467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.