Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | protein C (inactivator of coagulation factors Va and VIIIa) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus granulosus | Mastin | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | Mastin | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | enteropeptidase | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus granulosus | enteropeptidase | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | glycoprotein Antigen 5 | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0052 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0052 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0052 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0027 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0027 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Brugia malayi | sulfakinin receptor protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0052 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Echinococcus granulosus | enteropeptidase | 0.0052 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0027 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0027 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0027 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0027 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0027 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.1 uM | Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis | ChEMBL. | 24418773 |
IC50 (binding) | = 28 uM | Inhibition of human thrombin using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis | ChEMBL. | 24418773 |
Ki (binding) | = 0.9 uM | Competitive inhibition of human APC using S-2366 as substrate | ChEMBL. | 24418773 |
Ki (binding) | = 15 uM | Competitive inhibition of human thrombin using S-2366 as substrate | ChEMBL. | 24418773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.