Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0297 | 0.0297 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.6792 | 0.6792 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.5407 | 0.5267 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0297 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.6792 | 0.6792 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0297 | 0.0297 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.5407 | 0.5267 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 0.5407 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.5407 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6792 | 0.6792 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.5407 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.6792 | 0.6792 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0037 | 0.5407 | 0.5 |
Onchocerca volvulus | 0.001 | 0.0297 | 0.5 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0297 | 0.0297 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0037 | 0.5407 | 0.5407 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6792 | 0.6792 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.6792 | 0.6693 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0297 | 0.0297 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0037 | 0.5407 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0297 | 0.0297 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.5407 | 0.5267 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0037 | 0.5407 | 0.5407 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 0.5407 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0297 | 0.0297 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.5407 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0037 | 0.5407 | 0.5407 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0297 | 0.0297 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0297 | 0.0297 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.5407 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0037 | 0.5407 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0297 | 0.0297 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.5407 | 0.5267 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0297 | 0.0297 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0297 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6792 | 0.6792 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.6792 | 0.6693 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0297 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0297 | 0.0297 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.6792 | 0.6792 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0297 | 0.0297 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0297 | 0.0297 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0297 | 0.0297 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0037 | 0.5407 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 162 mg kg-1 | Acute toxicity in ip dosed ICR mouse | ChEMBL. | 24445313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.