Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.0427 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Brugia malayi | Trypsin family protein | 0.0321 | 0.0586 | 0.0586 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Onchocerca volvulus | 0.0321 | 0.0586 | 0.0725 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0878 | 0.0878 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0427 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0302 | 0.0302 |
Onchocerca volvulus | 0.0964 | 0.2362 | 1 | |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0036 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | = 2.5 % | Drug metabolism in human liver microsomes at 5 uM at 37 degC after 15 mins | ChEMBL. | 24446688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.