Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | oxoeicosanoid (OXE) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | oxoeicosanoid (OXE) receptor 1 | 423 aa | 363 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0066 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0066 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 | |
Brugia malayi | Trypsin family protein | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0066 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.55 uM | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis | ChEMBL. | 24351031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.