Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1077 | 0.3588 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1077 | 0.3588 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Brugia malayi | hypothetical protein | 0.0108 | 0.1077 | 0.3588 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0145 | 0.157 | 0.5227 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0145 | 0.157 | 0.5227 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0386 | 0.1287 |
Onchocerca volvulus | 0.0145 | 0.157 | 0.5227 | |
Brugia malayi | LBP/BPI | 0.0108 | 0.1077 | 0.3588 |
Onchocerca volvulus | 0.0108 | 0.1077 | 0.3588 | |
Onchocerca volvulus | 0.0056 | 0.0386 | 0.1287 | |
Echinococcus multilocularis | tumor protein p63 | 0.0383 | 0.4715 | 0.4616 |
Brugia malayi | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0184 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0145 | 0.157 | 0.5227 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0184 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0145 | 0.157 | 0.5227 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.0386 | 0.0206 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0253 | 0.3003 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.1077 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0145 | 0.157 | 0.5227 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0184 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.3003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1077 | 0.3588 |
Onchocerca volvulus | 0.0145 | 0.157 | 0.5227 | |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1077 | 0.3588 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0253 | 0.3003 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0253 | 0.3003 | 1 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Brugia malayi | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.157 | 0.5227 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0253 | 0.3003 | 1 |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Onchocerca volvulus | 0.0253 | 0.3003 | 1 | |
Echinococcus granulosus | tumor protein p63 | 0.0383 | 0.4715 | 0.4616 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5.15 % | Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as necrotic cells at 1.1 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.37%) | ChEMBL. | 24561675 |
IC50 (functional) | = 2.2 uM | Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as inhibition of parasite proliferation after 5 days by hemocytometer analysis | ChEMBL. | 24561675 |
Inhibition (binding) | Inhibition of Trypanosoma cruzi catalytic activity of cruzain using Z-FR-AMC as substrate at 100 uM after 10 mins by fluorescence assay | ChEMBL. | 26231082 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24561675 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.