Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal protective protein | 0.0402 | 0.4609 | 0.0899 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0402 | 0.4609 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0402 | 0.4609 | 0.0899 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0402 | 0.4609 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0394 | 0.4499 | 0.0713 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0402 | 0.4609 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0402 | 0.4609 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0402 | 0.4609 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.4025 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.3687 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0402 | 0.4609 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0402 | 0.4609 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.4025 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0402 | 0.4609 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0394 | 0.4499 | 0.0713 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0402 | 0.4609 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0402 | 0.4609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.4609 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 26000 nM | Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK cells co-expressing Gqi5 assessed as inhibition of dopamine-induced effect by FLIPR assay | ChEMBL. | 24393810 |
IC50 (binding) | = 4.24 uM | Inhibition of human recombinant MAO-A assessed as kynuramine oxidation to 4-hydroxyquinoline after 40 mins by LC-MS/MS analysis | ChEMBL. | 24393810 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline after 40 mins by LC-MS/MS analysis | ChEMBL. | 24393810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.