Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0099 | 0 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0263 | 1 | 0.5 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | subtilase | 0.0263 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 10 (mg/kg); Activity between positive and negative control groups | ChEMBL. | 2562852 |
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 3.16 (mg/kg); not significantly different from negative control group | ChEMBL. | 2562852 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.