Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 44 uM | Inhibition of human thrombin using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis | ChEMBL. | 24418773 |
IC50 (binding) | > 44 uM | Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis | ChEMBL. | 24418773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.