Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2x APTT (functional) | = 428 uM | Concentration required to double the activated partial thromboplastin time in human plasma | ChEMBL. | 15149685 |
Ki (binding) | = 0.652 uM | In vitro inhibition of human thrombin. | ChEMBL. | 15149685 |
Ki (binding) | = 0.652 uM | In vitro inhibition of human thrombin. | ChEMBL. | 15149685 |
Ki (binding) | = 81 uM | In vitro inhibition of Coagulation factor Xa. | ChEMBL. | 15149685 |
Ki (binding) | = 81 uM | In vitro inhibition of Coagulation factor Xa. | ChEMBL. | 15149685 |
Ki (binding) | > 200 uM | In vitro inhibition of bovine trypsin. | ChEMBL. | 15149685 |
Ki (binding) | > 200 uM | In vitro inhibition of bovine trypsin. | ChEMBL. | 15149685 |
pKa | = 6.1 | Dissociation constant of the compound was evaluated | ChEMBL. | 15149685 |
PT (functional) | = 435 uM | Concentration required to double the prothrombin time in human plasma | ChEMBL. | 15149685 |
Selectivity (binding) | > 300 | Selectivity for inhibition of thrombin over trypsin. | ChEMBL. | 15149685 |
TT (functional) | = 125 uM | Concentration required to double the thrombin time in human plasma | ChEMBL. | 15149685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.