Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0262 | 0.3072 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0262 | 0.3072 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0262 | 0.3072 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0262 | 0.3072 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2181 | 0.2181 |
Echinococcus multilocularis | lysosomal protective protein | 0.0262 | 0.3072 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0262 | 0.3072 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0262 | 0.3072 | 0.5 |
Echinococcus granulosus | lysosomal protective protein | 0.0262 | 0.3072 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0262 | 0.3072 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0262 | 0.3072 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.3072 | 0.3072 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0262 | 0.3072 | 0.5 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0262 | 0.3072 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0262 | 0.3072 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0262 | 0.3072 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 11 mm | Antibacterial activity against Escherichia coli at 500 ug/0.1 mL after 24 hr by agar diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.