Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.0754 | 0.6319 | 0.6929 |
Onchocerca volvulus | 0.0268 | 0.1266 | 1 | |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0816 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.088 | 0.088 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | glutamate receptor | 0.0354 | 0.2162 | 0.2162 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0781 | 0.6593 | 0.7229 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0231 | 0.088 | 0.1122 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0231 | 0.088 | 0.088 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0754 | 0.6319 | 0.6319 |
Trichomonas vaginalis | set domain proteins, putative | 0.0268 | 0.1266 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.0928 | 0.1184 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0754 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0231 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0439 | 0.3042 | 0.3335 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0781 | 0.6593 | 0.6593 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0439 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | glutamate receptor | 0.09 | 0.7838 | 0.7838 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.09 | 0.7838 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1024 | 0.912 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0781 | 0.6593 | 0.6593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Acute toxicity in Mus musculus ddY (mouse) assessed as mortality at 30 mg/kg, po | ChEMBL. | No reference | |
Activity (ADMET) | Acute toxicity in Mus musculus ddY (mouse) assessed as mortality at 300 mg/kg, po | ChEMBL. | No reference | |
Activity (ADMET) | Acute toxicity in Mus musculus ddY (mouse) assessed as mortality at 3 mg/kg, po | ChEMBL. | No reference | |
Activity (ADMET) | Acute toxicity in po dosed Mus musculus (mouse) | LITERATURE. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.