Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0393 | 1 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0393 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0393 | 1 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0393 | 1 | 1 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0393 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0393 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0393 | 1 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0393 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diuresis (functional) | = 23 ml kg-1 | Urinary volume excreted over 4 h by rats after oral administration of 30 mg/kg | ChEMBL. | 9703469 |
logP (ADMET) | = 2.57 | Partition coefficient (logP) | ChEMBL. | 9703469 |
No. of mice protected (functional) | = 1 | Tested for anticonvulsant activity by measuring rate of mice protected against electric shock applied at 0.5 h after injection in maximal electroshock seizure(MES)test; out of 6 | ChEMBL. | 9703469 |
No. of mice protected (functional) | = 4 | Tested for anticonvulsant activity by measuring rate of mice protected against electric shock applied at 3 h after injection in maximal electroshock seizure(MES)test; out of 7 | ChEMBL. | 9703469 |
No. of mice protected (functional) | = 1 | Tested for anticonvulsant activity by measuring rate of mice protected against electric shock applied at 0.5 h after injection in maximal electroshock seizure(MES)test; out of 6 | ChEMBL. | 9703469 |
No. of mice protected (functional) | = 4 | Tested for anticonvulsant activity by measuring rate of mice protected against electric shock applied at 3 h after injection in maximal electroshock seizure(MES)test; out of 7 | ChEMBL. | 9703469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.