Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, TTK | 0.541 | 1 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.541 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.541 | 1 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.541 | 1 | 1 |
Loa Loa (eye worm) | TTK protein kinase | 0.541 | 1 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.541 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.541 | 1 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.541 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of cyclooxygenase-2 in Homo sapiens (human) whole blood assessed as LPS-induced PGE2 production at 10 uM incubated 15 min prior to LPS challenge measured after 24 hr by enzyme immunoassay | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of cyclooxygenase-2 in Homo sapiens (human) whole blood assessed as LPS-induced PGE2 production at 100 uM incubated 15 min prior to LPS challenge measured after 24 hr by enzyme immunoassay | ChEMBL. | No reference | |
Inhibition (binding) | = 20 % | Inhibition of cyclooxygenase-1 in Homo sapiens (human) whole blood assessed as thromboxane B2 production at 10 uM after 1 hr by enzyme immunoassay | ChEMBL. | No reference |
Inhibition (binding) | = 88 % | Inhibition of cyclooxygenase-1 in Homo sapiens (human) whole blood assessed as thromboxane B2 production at 100 uM after 1 hr by enzyme immunoassay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.