Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.1305 | 0.2944 | 0.5 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0404 | 0.071 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.0041 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0134 | 0.0041 | 0.0041 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0404 | 0.071 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.4151 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.1692 | 0.3904 | 0.6563 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0941 | 0.2042 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.0041 | 0.0042 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.2517 | 0.5948 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0134 | 0.0041 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.0041 | 0.0042 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0134 | 0.0041 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.4091 | 0.9853 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.4151 | 1 | 1 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0404 | 0.071 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0134 | 0.0041 | 0.0041 |
Brugia malayi | SRC-1 | 0.0134 | 0.0041 | 0.007 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.1305 | 0.2944 | 0.2944 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0134 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0134 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0134 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.1305 | 0.2944 | 0.2944 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.1305 | 0.2944 | 0.495 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.0041 | 0.0042 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.1305 | 0.2944 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0134 | 0.0041 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0134 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | SRC-1 | 0.0134 | 0.0041 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0134 | 0.0041 | 0.0041 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0404 | 0.071 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0134 | 0.0041 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.1692 | 0.3904 | 0.3904 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0404 | 0.071 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0134 | 0.0041 | 0.0041 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0134 | 0.0041 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0134 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.0041 | 0.0041 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0404 | 0.071 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0134 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.1575 | 0.3613 | 0.3613 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.1305 | 0.2944 | 0.2989 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.1305 | 0.2944 | 0.2944 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0134 | 0.0041 | 0.0041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Candida albicans ATCC 2091 after 24 hrs by broth microdilution method | ChEMBL. | 24239622 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | ChEMBL. | 24239622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.