Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein VI (platelet) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.4062 | 0.346 | 0.3772 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.2136 | 0.1427 | 0.1792 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.698 | 0.654 | 0.713 |
Schistosoma mansoni | hypothetical protein | 0.1352 | 0.0601 | 0.0655 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.2136 | 0.1427 | 0.1427 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.8333 | 0.7968 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.1352 | 0.0601 | 0.0601 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.9475 | 0.9173 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.1352 | 0.0601 | 1 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0783 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 1.0258 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.4062 | 0.346 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 1.0258 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.7549 | 0.7141 | 0.8962 |
Loa Loa (eye worm) | glutamate receptor | 0.3278 | 0.2633 | 0.2633 |
Loa Loa (eye worm) | hypothetical protein | 0.2136 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | glutamate receptor | 0.8333 | 0.7968 | 0.7968 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.698 | 0.654 | 0.654 |
Leishmania major | extracellular receptor, putative | 0.0783 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.1352 | 0.0601 | 0.0601 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.698 | 0.654 | 0.654 |
Entamoeba histolytica | hypothetical protein | 0.0783 | 0 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.1352 | 0.0601 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.2136 | 0.1427 | 0.1427 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.1352 | 0.0601 | 0.0754 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins followed by CVX addition measured after 5 mins by turbidimetric method | LITERATURE. | 27996269 |
IC50 (binding) | = 25.3 uM | Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 mins followed by collagen addition measured after 5 mins by turbidimetric method | LITERATURE. | 27996269 |
IC50 (binding) | = 181.4 uM | Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mins followed by CRP-XL addition measured after 5 mins by turbidimetric method | LITERATURE. | 27996269 |
Inhibition (binding) | Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 mins followed by collagen addition measured after 5 mins by turbidimetric method | LITERATURE. | 27996269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.