Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0136 | 0.7273 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5622 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0136 | 0.7273 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.1439 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0136 | 0.7273 | 0.6695 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.3536 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8068 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.377 | 0.245 |
Brugia malayi | Isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.