Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.1439 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8068 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0136 | 0.7273 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0136 | 0.7273 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.6695 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0136 | 0.7273 | 0.6695 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5622 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.3536 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0136 | 0.7273 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0136 | 0.7273 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.377 | 0.245 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0136 | 0.7273 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0136 | 0.7273 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.