Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin degrading enzyme | 0.009 | 1 | 1 |
Echinococcus granulosus | 3'partial|nardilysin | 0.009 | 1 | 1 |
Toxoplasma gondii | insulysin, putative | 0.0085 | 0.9093 | 0.9093 |
Schistosoma mansoni | insulysin (M16 family) | 0.005 | 0.2738 | 0.2738 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.009 | 1 | 0.5 |
Trypanosoma brucei | peptidase, putative | 0.009 | 1 | 0.5 |
Toxoplasma gondii | sporozoite developmental protein | 0.009 | 1 | 1 |
Toxoplasma gondii | toxolysin TLN4 | 0.004 | 0.0907 | 0.0907 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0089 | 0.9897 | 0.9897 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0089 | 0.9897 | 0.9897 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.009 | 1 | 1 |
Echinococcus multilocularis | nardilysin | 0.009 | 1 | 1 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0054 | 0.3542 | 0.3542 |
Echinococcus granulosus | insulin degrading enzyme | 0.009 | 1 | 1 |
Schistosoma mansoni | nardilysin (M16 family) | 0.009 | 1 | 1 |
Trypanosoma cruzi | peptidase, putative | 0.009 | 1 | 0.5 |
Chlamydia trachomatis | insulinase family protease III | 0.009 | 1 | 0.5 |
Schistosoma mansoni | nardilysin (M16 family) | 0.009 | 1 | 1 |
Echinococcus multilocularis | nardilysin | 0.009 | 1 | 1 |
Trypanosoma cruzi | peptidase, putative | 0.009 | 1 | 0.5 |
Echinococcus granulosus | nardilysin | 0.009 | 1 | 1 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.009 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.