Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.0022 | 0.0024 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0257 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1455 | 0.6965 | 0.8881 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0783 | 0.3057 | 0.3898 |
Plasmodium vivax | lactate dehydrogenase | 0.0257 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0412 | 0.0899 | 0.0899 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1345 | 0.6327 | 0.6936 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0257 | 0 | 0.5 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0257 | 0 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0412 | 0.0899 | 0.1147 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0257 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1606 | 0.7843 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0261 | 0.0022 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0783 | 0.3057 | 0.3351 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1977 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0632 | 0.2179 | 0.2179 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1826 | 0.9122 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0261 | 0.0022 | 0.0028 |
Plasmodium falciparum | malate dehydrogenase | 0.0257 | 0 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0257 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.1345 | 0.6327 | 0.6327 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0899 | 0.0899 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0257 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0261 | 0.0022 | 0.5 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0261 | 0.0022 | 0.0022 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0261 | 0.0022 | 0.0022 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0257 | 0 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0412 | 0.0899 | 0.0899 |
Loa Loa (eye worm) | glutamate receptor | 0.1606 | 0.7843 | 0.7843 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.1345 | 0.6327 | 0.6327 |
Leishmania major | malate dehydrogenase, putative | 0.0257 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.