TDR Targets

Basic information

Technical information

TDR Targets ID: 184469
Name: 1-(2-ethyl-6-propan-2-ylphenyl)-3-[(1-phenylc yclopentyl)methyl]urea
MW: 364.524 | Formula: C24H32N2O
H donors: 2 H acceptors: 1 LogP: 6.18 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCc1cccc(c1NC(=O)NCC1(CCCC1)c1ccccc1)C(C)C
InChi: 1S/C24H32N2O/c1-4-19-11-10-14-21(18(2)3)22(19)26-23(27)25-17-24(15-8-9-16-24)20-12-6-5-7-13-20/h5-7,10-14,18H,4,8-9,15-17H2,1-3H3,(H2,25,26,27)
InChiKey: LTPXLYHQNFPPCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-ethyl-6-isopropyl-phenyl)-3-[(1-phenylcyclopentyl)methyl]urea
1-(2-ethyl-6-isopropylphenyl)-3-[(1-phenylcyclopentyl)methyl]urea
1-(2-ethyl-6-propan-2-yl-phenyl)-3-[(1-phenylcyclopentyl)methyl]urea
3-(2-ethyl-6-propan-2-ylphenyl)-1-[(1-phenylcyclopentyl)methyl]urea
3-(2-ethyl-6-isopropyl-phenyl)-1-[(1-phenylcyclopentyl)methyl]urea
3-(2-ethyl-6-isopropylphenyl)-1-[(1-phenylcyclopentyl)methyl]urea
3-(2-ethyl-6-propan-2-yl-phenyl)-1-[(1-phenylcyclopentyl)methyl]urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Acyl-CoA:cholesterol acyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma mansoni	sterol O-acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma japonicum	ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus multilocularis	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus granulosus	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	diacylglycerol O-acyltransferase 1	Acyl-CoA:cholesterol acyltransferase	305 aa	278 aa	21.9 %
Neospora caninum	sterol O-acyltransferase, putative	Acyl-CoA:cholesterol acyltransferase	305 aa	258 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	N chimaerin	0.0391	0.2925	0.3367
Onchocerca volvulus		0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0651	0.8688	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Echinococcus multilocularis	tensin	0.0391	0.2925	0.3367
Echinococcus multilocularis	signal transduction protein lnk realted	0.0391	0.2925	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0651	0.8688	1
Brugia malayi	SH2 domain containing protein	0.0651	0.8688	0.8688
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0651	0.8688	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0391	0.2925	0.3367
Schistosoma mansoni	growth factor receptor-bound protein	0.0391	0.2925	0.3367
Brugia malayi	Sex muscle abnormal protein 5	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Plasmodium vivax	protein kinase, putative	0.026	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0391	0.2925	0.3367
Trichomonas vaginalis	protein tyrosine kinase, putative	0.026	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0651	0.8688	1
Schistosoma mansoni	hypothetical protein	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein kinase shark	0.0651	0.8688	1
Echinococcus multilocularis	NCK adaptor protein	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0651	0.8688	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0391	0.2925	0.3367
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Entamoeba histolytica	SH2 domain containing protein	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0391	0.2925	0.2925
Brugia malayi	Tyrosine-protein kinase abl-1	0.0651	0.8688	0.8688
Schistosoma mansoni	growth factor receptor-bound protein	0.0391	0.2925	0.3367
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Schistosoma mansoni	SH2A	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Brugia malayi	Tensin	0.0391	0.2925	0.2925
Schistosoma mansoni	GTPase activating protein	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0651	0.8688	1
Schistosoma mansoni	tensin	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase shark	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0651	0.8688	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.026	0	0.5
Onchocerca volvulus		0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Echinococcus multilocularis	SHC transforming protein 3	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0651	0.8688	1
Brugia malayi	protein-tyrosine kinase	0.0651	0.8688	0.8688
Loa Loa (eye worm)	hypothetical protein	0.0476	0.4806	0.4806
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0651	0.8688	1
Schistosoma mansoni	vav2	0.0391	0.2925	0.3367
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Giardia lamblia	Kinase, NEK	0.026	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0391	0.2925	0.3367
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.026	0	0.5
Echinococcus multilocularis	SH2 motif	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0651	0.8688	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0391	0.2925	0.3367
Giardia lamblia	Kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0391	0.2925	0.2925
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0651	0.8688	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0391	0.2925	0.3367
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0651	0.8688	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0391	0.2925	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Echinococcus granulosus	tensin	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0651	0.8688	0.8688
Plasmodium vivax	tyrosine kinase-like protein, putative	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0651	0.8688	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0651	0.8688	0.8688
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0391	0.2925	0.3367
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0391	0.2925	0.2925
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.026	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0391	0.2925	0.2925
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0391	0.2925	0.2925
Brugia malayi	SRC-1	0.0651	0.8688	0.8688
Echinococcus multilocularis	sterol O acyltransferase 1	0.0528	0.595	0.6849
Schistosoma mansoni	adapter molecule crk	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Onchocerca volvulus		0.0651	0.8688	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0651	0.8688	1
Schistosoma mansoni	hypothetical protein	0.0391	0.2925	0.3367
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0391	0.2925	0.3367
Schistosoma mansoni	sterol O-acyltransferase 1	0.0528	0.595	0.6849
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0651	0.8688	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Onchocerca volvulus		0.0391	0.2925	0.3367
Echinococcus multilocularis	N chimaerin	0.0391	0.2925	0.3367
Trichomonas vaginalis	STE family protein kinase	0.026	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.026	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0651	0.8688	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.026	0	0.5
Toxoplasma gondii	STE kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0651	0.8688	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Leishmania major	protein kinase, putative	0.026	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0391	0.2925	0.2925
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.026	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0391	0.2925	0.2925
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.026	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.026	0	0.5
Onchocerca volvulus		0.0391	0.2925	0.3367
Onchocerca volvulus		0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0391	0.2925	0.2925
Plasmodium falciparum	tyrosine kinase-like protein	0.026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0651	0.8688	0.8688
Schistosoma mansoni	tensin-related	0.0391	0.2925	0.3367
Onchocerca volvulus		0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0391	0.2925	0.2925
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Toxoplasma gondii	protein kinase	0.026	0	0.5
Onchocerca volvulus		0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine kinase	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0391	0.2925	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Leishmania major	hypothetical protein, conserved	0.026	0	0.5
Schistosoma mansoni	shc transforming protein	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Schistosoma mansoni	tensin	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.026	0	0.5
Echinococcus granulosus	SH2 motif	0.0391	0.2925	0.3367
Schistosoma mansoni	nck2/grb4	0.0391	0.2925	0.3367
Echinococcus multilocularis		0.0391	0.2925	0.3367
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0391	0.2925	0.3367
Trypanosoma brucei	Pseudokinase, putative	0.026	0	0.5
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Loa Loa (eye worm)	SRC-1	0.0651	0.8688	0.8688
Loa Loa (eye worm)	hypothetical protein	0.0651	0.8688	0.8688
Trypanosoma brucei	Flagellum attachment zone protein 20	0.026	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0391	0.2925	0.3367
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.026	0	0.5
Echinococcus multilocularis	tensin	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0651	0.8688	0.8688
Echinococcus granulosus	tyrosine protein kinase Blk	0.0651	0.8688	1
Echinococcus granulosus	hypothetical protein	0.0391	0.2925	0.3367
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0651	0.8688	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0391	0.2925	0.3367
Plasmodium falciparum	protein kinase, putative	0.026	0	0.5
Giardia lamblia	Kinase, NEK	0.026	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Loa Loa (eye worm)	hypothetical protein	0.0528	0.595	0.595
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.026	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0651	0.8688	1
Echinococcus granulosus	SHC transforming protein 3	0.0391	0.2925	0.3367
Trichomonas vaginalis	TK family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0391	0.2925	0.2925
Brugia malayi	SH2 domain containing protein	0.0651	0.8688	0.8688
Trichomonas vaginalis	AGC family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Schistosoma mansoni	tensin-related	0.0391	0.2925	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Plasmodium falciparum	protein kinase, putative	0.026	0	0.5
Loa Loa (eye worm)	STAT protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.071	1	1
Echinococcus granulosus	expressed conserved protein	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine kinase	0.0651	0.8688	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0651	0.8688	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0391	0.2925	0.3367
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	hypothetical protein	0.0391	0.2925	0.2925
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0651	0.8688	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0651	0.8688	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0391	0.2925	0.3367
Onchocerca volvulus		0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0391	0.2925	0.3367
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0391	0.2925	0.3367
Brugia malayi	Variant SH3 domain containing protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0651	0.8688	1
Echinococcus granulosus	sterol O acyltransferase 1	0.0528	0.595	0.6849
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0651	0.8688	0.8688
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0651	0.8688	0.8688
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.026	0	0.5
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Schistosoma mansoni	tyrosine kinase	0.0651	0.8688	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Leishmania major	protein kinase, putative	0.026	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0391	0.2925	0.3367
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0651	0.8688	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0391	0.2925	0.2925
Giardia lamblia	Protein 21.1	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trypanosoma brucei	protein kinase, putative	0.026	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0651	0.8688	1
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.026	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0391	0.2925	0.3367
Brugia malayi	SH2 domain containing protein	0.0391	0.2925	0.2925
Onchocerca volvulus		0.0651	0.8688	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0391	0.2925	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0391	0.2925	0.2925
Brugia malayi	Protein kinase domain containing protein	0.0651	0.8688	0.8688
Schistosoma mansoni	tensin	0.0391	0.2925	0.3367
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0391	0.2925	0.3367
Toxoplasma gondii	protein kinase domain-containing protein	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Onchocerca volvulus		0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	SH2 motif	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus multilocularis	SH2 motif	0.0391	0.2925	0.3367
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0651	0.8688	1
Echinococcus granulosus	NCK adaptor protein	0.0391	0.2925	0.3367
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0391	0.2925	0.3367
Brugia malayi	Variant SH3 domain containing protein	0.0391	0.2925	0.2925
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0391	0.2925	0.3367
Loa Loa (eye worm)	TK/FER protein kinase	0.0651	0.8688	0.8688
Loa Loa (eye worm)	SH2 domain-containing protein	0.0391	0.2925	0.2925
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0651	0.8688	1
Trichomonas vaginalis	TKL family protein kinase	0.026	0	0.5
Brugia malayi	hypothetical protein	0.0651	0.8688	0.8688
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0391	0.2925	0.3367
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.026	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.026	0	0.5
Echinococcus granulosus	SH2 motif	0.0391	0.2925	0.3367
Onchocerca volvulus		0.0651	0.8688	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= -59 %	Percent change in total cholesterol (TC) in cholic acid, cholesterol and peanut oil fed rats	ChEMBL.	8230120
IC50 (binding)	= 0.025 uM	In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase using intestinal microsomes isolated from cholesterol fed rabbits	ChEMBL.	8230120
IC50 (binding)	= 0.025 uM	In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase using intestinal microsomes isolated from cholesterol fed rabbits	ChEMBL.	8230120

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113158
PubChem: 14977539

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 184469