Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0184 | 0.4678 | 0.4678 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0184 | 0.4678 | 0.4643 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0184 | 0.4678 | 0.4643 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0184 | 0.4678 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1493 | 0.1437 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0184 | 0.4678 | 0.4643 |
Brugia malayi | DNA topoisomerase I | 0.0184 | 0.4678 | 1 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0184 | 0.4678 | 0.5 |
Plasmodium vivax | topoisomerase I, putative | 0.0184 | 0.4678 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.4527 | 0.4491 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.4593 | 0.4557 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0184 | 0.4678 | 0.4643 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.4527 | 0.4491 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.033 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1493 | 0.1437 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.4527 | 0.4491 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.4527 | 0.4527 |
Echinococcus multilocularis | snurportin 1 | 0.033 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1456 | 0.14 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1493 | 0.1493 |
Echinococcus granulosus | geminin | 0.0182 | 0.4593 | 0.4557 |
Echinococcus multilocularis | geminin | 0.0182 | 0.4593 | 0.4593 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1493 | 0.1437 |
Plasmodium falciparum | topoisomerase I | 0.0184 | 0.4678 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1493 | 0.1437 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0184 | 0.4678 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.4593 | 0.4557 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1456 | 0.14 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0184 | 0.4678 | 0.4643 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.4527 | 0.9673 |
Brugia malayi | RNA, U transporter 1 | 0.0088 | 0.1175 | 0.2405 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1456 | 0.14 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0184 | 0.4678 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 310 nM | Inhibition of human recombinant GST-fused HER2 expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
IC50 (binding) | > 1000000 nM | Inhibition of human recombinant GST-fused Brk expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.