Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ubiquitin activating enzyme, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.3971 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 1 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0135 | 0.6761 | 0.6348 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3897 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.3971 | 0.32 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0135 | 0.6761 | 0.6348 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3971 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3897 | 0.3117 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.1133 | 0.0145 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.3971 | 0.3299 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0135 | 0.6761 | 0.6401 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0135 | 0.6761 | 0.6348 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0042 | 0 | 0.5 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0135 | 0.6761 | 0.5 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0098 | 0.4031 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3897 | 0.3117 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0135 | 0.6761 | 0.6348 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3971 | 0.32 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0135 | 0.6761 | 0.5 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.1133 | 0.0145 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0042 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 376 nM | Inhibition of human recombinant GST-fused HER2 expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
IC50 (binding) | > 1000000 nM | Inhibition of human recombinant GST-fused Brk expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.