TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 861.116 | Formula: C46H76N4O11
H donors: 7 H acceptors: 8 LogP: 5.26 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)OC[C@@H]1OC(O)[C@H]([C@H]([C@@H]1O)O[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N)CCC(=O)O)C)C)NC(=O)C)C)C
InChi: 1S/C46H76N4O11/c1-24(2)10-9-11-25(3)32-14-15-33-31-13-12-29-22-30(18-20-45(29,7)34(31)19-21-46(32,33)8)59-23-36-39(54)40(38(44(58)61-36)49-28(6)51)60-27(5)43(57)48-26(4)42(56)50-35(41(47)55)16-17-37(52)53/h12,24-27,30-36,38-40,44,54,58H,9-11,13-23H2,1-8H3,(H2,47,55)(H,48,57)(H,49,51)(H,50,56)(H,52,53)/t25-,26+,27+,30+,31+,32-,33+,34+,35-,36+,38+,39-,40-,44?,45+,46-/m1/s1
InChiKey: XBUDVRQHROMDQW-DUTXHJRKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0053	0	0.5
Toxoplasma gondii	STE kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0053	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	SRC-1	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0055	1	1
Onchocerca volvulus		0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Leishmania major	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0053	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0053	0	0.5
Schistosoma mansoni	protein kinase	0.0055	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0053	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	SRC-1	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Brugia malayi	Raf kinase	0.0053	0	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0053	0	0.5
Brugia malayi	integrin-linked kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0053	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Schistosoma mansoni	protein kinase	0.0055	1	1
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0053	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0053	0	0.5
Brugia malayi	SH2 domain containing protein	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Leishmania major	hypothetical protein, conserved	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Leishmania major	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Brugia malayi	SH2 domain containing protein	0.0053	0	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	hypothetical protein	0.0053	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Giardia lamblia	Kinase, NEK	0.0055	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0053	0	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0053	0	0.5
Brugia malayi	hypothetical protein	0.0053	0	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0053	0	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Onchocerca volvulus		0.0053	0	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0055	1	1
Toxoplasma gondii	protein kinase	0.0053	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0053	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0053	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Plasmodium vivax	protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0053	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Brugia malayi	hypothetical protein	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0053	0	0.5
Entamoeba histolytica	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0053	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0053	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0053	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3143614

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1846518