Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0255 | 0.5065 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0982 | 0.1939 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1008 | 0.1991 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1008 | 0.1991 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0982 | 0.1939 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0079 | 0.0546 | 0.5 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0255 | 0.5065 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0079 | 0.0546 | 0.5 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0255 | 0.5065 | 1 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0079 | 0.0546 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1008 | 0.1991 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0255 | 0.5065 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0255 | 0.5065 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1008 | 0.1991 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1008 | 0.1991 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0255 | 0.5065 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.3151 | 0.6221 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0079 | 0.0546 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.3151 | 0.6221 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0184 | 0.324 | 1 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0079 | 0.0546 | 0.5 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0079 | 0.0546 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.3151 | 0.6221 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.3151 | 0.6221 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0982 | 0.1939 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0255 | 0.5065 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.3151 | 0.6221 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.39 uM | Cytotoxicity against gefitinib-resistant human NCI-H1975 cells expressing EGFR L858R/T790M double mutant assessed as growth inhibition incubated for 1 hr prior to EGF challenge measured after 72 hrs by luciferase reporter gene assay | ChEMBL. | No reference |
IC50 (binding) | = 1.5 uM | Inhibition of recombinant wild type EGFR kinase(unknown origin) after 30 mins in presence of [gamma32P]ATP | ChEMBL. | No reference |
IC50 (binding) | = 111 uM | Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as inhibition of EGF-mediated autophosphorylation incubated for 30 mins prior to EGF challenge by cytoblot assay | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.