Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.035 | 0.4742 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0554 | 0.9326 | 0.9122 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0554 | 0.9326 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.035 | 0.4742 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0554 | 0.9326 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0554 | 0.9326 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0343 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0584 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0554 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0584 | 1 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0584 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.0343 | 0.4584 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0554 | 0.9326 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0584 | 1 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.035 | 0.4742 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0554 | 0.9326 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0343 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.035 | 0.4742 | 0.0000097958 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0584 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0554 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 24.3 % | In vitro cytotoxicity of the compound against L1210 cells at a dose 50 microg/mL | ChEMBL. | 2709380 |
Survival (functional) | = 74 % | In vitro cytotoxicity of the compound against L1210 cells at a dose 10 microg/mL | ChEMBL. | 2709380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.