Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0147 | 0.7414 | 0.7414 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0183 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0147 | 0.7414 | 0.7414 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0071 | 0.193 | 0.193 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | Mastin | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0183 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0183 | 1 | 1 |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.7059 | 0.7059 |
Echinococcus multilocularis | enteropeptidase | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0147 | 0.7414 | 0.7414 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.7414 | 0.6978 |
Brugia malayi | Trypsin family protein | 0.0147 | 0.7414 | 0.7414 |
Mycobacterium ulcerans | hypothetical protein | 0.0147 | 0.7414 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0071 | 0.193 | 0.0569 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0071 | 0.193 | 0.0569 |
Echinococcus granulosus | prolyl endopeptidase | 0.0142 | 0.7059 | 0.6563 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0142 | 0.7059 | 0.6563 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Echinococcus multilocularis | Mastin | 0.0147 | 0.7414 | 0.6978 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0071 | 0.193 | 0.0764 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Trypanosoma brucei | prolyl endopeptidase | 0.0142 | 0.7059 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0071 | 0.193 | 0.0764 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Brugia malayi | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | enteropeptidase | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Brugia malayi | Trypsin family protein | 0.0147 | 0.7414 | 0.7414 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0142 | 0.7059 | 0.7059 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0183 | 1 | 1 |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0147 | 0.7414 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0115 | 0.5128 | 1 |
Brugia malayi | Trypsin family protein | 0.0147 | 0.7414 | 0.7414 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0142 | 0.7059 | 0.6563 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0071 | 0.193 | 0.0764 |
Loa Loa (eye worm) | trypsin family protein | 0.0147 | 0.7414 | 0.7414 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0142 | 0.7059 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0071 | 0.193 | 0.0764 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0065 | 0.1506 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0071 | 0.193 | 0.0764 |
Toxoplasma gondii | prolyl endopeptidase | 0.0142 | 0.7059 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.7414 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0659 | 0.0659 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0071 | 0.193 | 0.0569 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.7414 | 0.7414 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0183 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0142 | 0.7059 | 0.6563 |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0142 | 0.7059 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0142 | 0.7059 | 0.6563 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0147 | 0.7414 | 0.6978 |
Onchocerca volvulus | 0.0147 | 0.7414 | 0.6978 | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0147 | 0.7414 | 0.6978 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Compound was tested for the inhibition of Fucosyltransferase 4 alpha 1,3 at 8.5 microM GDP-fucose | ChEMBL. | No reference |
IC50 (binding) | = 67 uM | Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine | ChEMBL. | 11459637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.