Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol transporter | 0.183 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.2309 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0467 | 0.2309 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.183 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.183 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0467 | 0.2309 | 1 |
Plasmodium falciparum | hexose transporter | 0.0058 | 0 | 0.5 |
Brugia malayi | GH02984p | 0.0467 | 0.2309 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0467 | 0.2309 | 0.2309 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.183 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0467 | 0.2309 | 0.2309 |
Echinococcus multilocularis | solute carrier family 5 | 0.183 | 1 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0467 | 0.2309 | 0.2309 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0467 | 0.2309 | 0.2309 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.183 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.2309 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0467 | 0.2309 | 0.2309 |
Schistosoma mansoni | high-affinity choline transporter | 0.0467 | 0.2309 | 0.2309 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.183 | 1 | 1 |
Plasmodium vivax | hexose transporter | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | 0.0467 | 0.2309 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Compound was tested for its inhibition against Thymidylate synthase up to concentration of 1 mM; IA means inactive | ChEMBL. | 6779007 | |
Inhibition (functional) | = 11 % | In vitro percent inhibition at 10 e-8 M against L5178Y cell growth after 72 h (replicate flasks inoculated with 10 e5 cells were treated with the nucleotide) | ChEMBL. | 6779007 |
T1/2 (functional) | = 100 hr | Half-life of the compound for hydrolysis to 5-fluoro-2'-deoxyuridine-5'-phosphate at 100 degree centigrade | ChEMBL. | 6779007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.