Detailed information for compound 1847257

Basic information

Technical information
  • TDR Targets ID: 1847257
  • Name: 1-[(2R,4S,5R)-4-hydroxy-5-[(5-oxido-4-phenyls ulfonyl-1,2,5-oxadiazol-5-ium-3-yl)oxymethyl] oxolan-2-yl]pyrimidine-2,4-dione
  • MW: 452.395 | Formula: C17H16N4O9S
  • H donors: 2 H acceptors: 7 LogP: 0 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COc1no[n+](c1S(=O)(=O)c1ccccc1)[O-])n1ccc(=O)[nH]c1=O
  • InChi: 1S/C17H16N4O9S/c22-11-8-14(20-7-6-13(23)18-17(20)24)29-12(11)9-28-15-16(21(25)30-19-15)31(26,27)10-4-2-1-3-5-10/h1-7,11-12,14,22H,8-9H2,(H,18,23,24)/t11-,12+,14+/m0/s1
  • InChiKey: FHOSMOKEYPJCQK-OUCADQQQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2R,4S,5R)-4-hydroxy-5-[(5-oxido-4-phenylsulfonyl-1,2,5-oxadiazol-5-ium-3-yl)oxymethyl]tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-4-hydroxy-5-[(5-oxido-4-phenylsulfonyl-1,2,5-oxadiazol-5-ium-3-yl)oxymethyl]-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-4-hydroxy-5-[(5-oxido-4-phenylsulfonyl-furazan-5-ium-3-yl)oxymethyl]tetrahydrofuran-2-yl]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0025 0.0151
Echinococcus granulosus fmrfamide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0027 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0025 0.0151
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0025 0.0151
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0025 0.0151
Schistosoma mansoni twik family of potassium channels-related 0.0389 0.1623 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0025 0.0151
Echinococcus granulosus g protein coupled receptor 0.0033 0.0025 0.0151
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0025 0.0151
Brugia malayi putative neuropeptide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0025 0.0151
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0389 0.1623 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0389 0.1623 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0365 0.1518 0.9352
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0025 0.0151
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0389 0.1623 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0025 0.0151
Mycobacterium ulcerans malate synthase G 0.2253 1 1
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0389 0.1623 1
Schistosoma mansoni neuropeptide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0025 0.0151
Schistosoma mansoni amine GPCR 0.0033 0.0025 0.0151
Trypanosoma brucei carbonic anhydrase-like protein 0.0027 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Schistosoma mansoni amine GPCR 0.0033 0.0025 0.0151
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus sex peptide receptor 0.0033 0.0025 0.0151
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0025 0.0151
Schistosoma mansoni hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni opsin-like receptor 0.0033 0.0025 0.0151
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0025 0.0151
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0025 0.0151
Brugia malayi Serotonin receptor 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0025 0.0151
Brugia malayi neuropeptide F receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0025 0.0151
Echinococcus granulosus allatostatin A receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0025 0.0151
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0025 0.0151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0025 0.0151
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0025 0.0151
Schistosoma mansoni adenoreceptor 0.0033 0.0025 0.0151
Brugia malayi G-protein coupled receptor 0.0033 0.0025 0.0151
Schistosoma mansoni neuropeptide receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi Dopamine receptor 0.0033 0.0025 0.0151
Schistosoma mansoni opsin-like receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0025 0.0151
Schistosoma mansoni neuropeptide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0025 0.0151
Schistosoma mansoni opsin-like receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0025 0.0151
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni amine GPCR 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi sulfakinin receptor protein 0.0033 0.0025 0.0151
Echinococcus granulosus serotonin receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0389 0.1623 1
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Schistosoma mansoni amine GPCR 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0025 0.0151
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0025 0.0151
Mycobacterium tuberculosis Malate synthase G GlcB 0.2253 1 1
Echinococcus granulosus hypothetical protein 0.0033 0.0025 0.0151
Plasmodium falciparum carbonic anhydrase 0.0027 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0025 0.0151
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0025 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0025 0.0151
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0025 0.0151
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis serotonin receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis sex peptide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus granulosus g protein coupled receptor 0.0033 0.0025 0.0151
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0025 0.0151
Schistosoma mansoni hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi ORL1-like opioid receptor 0.0033 0.0025 0.0151
Echinococcus granulosus g protein coupled receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine receptor 0.0033 0.0025 0.0151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi Dopamine receptor protein 1 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0025 0.0151
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide receptor 0.0033 0.0025 0.0151
Wolbachia endosymbiont of Brugia malayi dihydrodipicolinate synthase 0.0113 0.0386 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Leishmania major carbonic anhydrase-like protein 0.0027 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0025 0.0151
Echinococcus multilocularis serotonin receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis somatostatin receptor 0.0033 0.0025 0.0151
Schistosoma mansoni myosin xvIII 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0025 0.0151
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Toxoplasma gondii dihydrodipicolinate synthase 0.0113 0.0386 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0025 0.0151
Schistosoma mansoni hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi Melatonin receptor type 1A 0.0033 0.0025 0.0151
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0025 0.0151
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0025 0.0151
Chlamydia trachomatis 4-hydroxy-tetrahydrodipicolinate synthase 0.0113 0.0386 0.5
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Schistosoma mansoni amine GPCR 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0025 0.0151
Brugia malayi neuropeptide F receptor 0.0033 0.0025 0.0151
Brugia malayi Dopamine receptor protein 2 0.0033 0.0025 0.0151
Trichomonas vaginalis dihydrodipicolinate synthase, putative 0.0113 0.0386 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0025 0.0151
Brugia malayi G-protein coupled receptor 0.0033 0.0025 0.0151
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0025 0.0151
Brugia malayi G protein-coupled receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0025 0.0151
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0025 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Brugia malayi RE15519p 0.0033 0.0025 0.0151
Schistosoma mansoni histamine h1 receptor 0.0033 0.0025 0.0151
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi AKH receptor 0.0033 0.0025 0.0151
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0025 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0025 0.0151
Brugia malayi hypothetical protein 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Brugia malayi Serotonin receptor 0.0033 0.0025 0.0151
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0025 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0025 0.0151
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0025 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0151
Brugia malayi larval opioid receptor 0.0033 0.0025 0.0151
Echinococcus granulosus orexin receptor type 2 0.0033 0.0025 0.0151
Onchocerca volvulus 0.0033 0.0025 0.5
Echinococcus granulosus somatostatin receptor 0.0033 0.0025 0.0151
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0025 0.5
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0027 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0025 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0025 0.0151
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0025 0.5
Brugia malayi GnHR receptor homolog 0.0033 0.0025 0.0151
Schistosoma mansoni neuropeptide receptor 0.0033 0.0025 0.0151

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 0.00000075 M In vitro cell cytotoxicity was determined against EMT-6 cell line ChEMBL. 15027876
CC50 (functional) = 0.0000033 M In vitro cell cytotoxicity was determined against 143B cell line ChEMBL. 15027876
CC50 (functional) = 0.0000048 M In vitro cell cytotoxicity was determined against Hs 578.Bst cell line ChEMBL. 15027876
CC50 (functional) = 0.0000063 M In vitro cell cytotoxicity was determined against 143B-LTK cell line ChEMBL. 15027876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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