Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0808 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0808 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0084 | 0.0621 | 0.0621 |
Echinococcus multilocularis | lysosomal protective protein | 0.0808 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 0.0621 | 0.0621 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0728 | 0.8966 | 0.8966 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0728 | 0.8966 | 0.8966 |
Echinococcus multilocularis | jun protein | 0.0084 | 0.0621 | 0.0621 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.0417 | 0.0417 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0388 | 0.0388 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0808 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 0.0621 | 0.0621 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0808 | 1 | 1 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.008 | 0.0569 | 0.0569 |
Echinococcus granulosus | jun protein | 0.0084 | 0.0621 | 0.0621 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0808 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0417 | 0.0417 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 600 nM | Inhibition of human recombinant aromatase expressed in baculovirus infected insect cells using O-benzylfluorescein benzyl ester as substrate after 30 mins | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.