Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Incorporation rate (functional) | = 171 c.p.m. hr-1 | Effect of the compound on DNA synthesis in mouse LM(TK-) cells blocked in DNA synthesis with Aminopterin at 10e-4 M | ChEMBL. | 3701790 |
Incorporation rate (functional) | = 673 c.p.m. hr-1 | Rate of incorporation of [3H]-dC into DNA in mouse L929 cells at 10e-4 concentration; units=cpm/hx 5*10e5 cells | ChEMBL. | 3701790 |
Incorporation rate (functional) | = 808 c.p.m. hr-1 | Compound was evaluated for stimulation of DNA synthesis in L929 cells in the presence of 5'-NH2-dT | ChEMBL. | 3701790 |
Incorporation rate (functional) | = 1103 c.p.m. hr-1 | Rate of incorporation of [3H]-dC into DNA in mouse L929 cells at 10e-4 concentration; units=cpm/hx 5*10e5 cells | ChEMBL. | 3701790 |
Incorporation rate (functional) | = 5462 c.p.m. hr-1 | Compound was evaluated for stimulation of DNA synthesis in L929 cells in the absence of 5'-NH2-dT | ChEMBL. | 3701790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.