Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Echinococcus granulosus | Mastin | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0088 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Brugia malayi | Trypsin family protein | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0088 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 131 nM | Antagonist activity at MCHR1 (unknown origin) assessed as IP3 levels by cell-based functional assay | ChEMBL. | No reference |
IC50 (binding) | = 138 nM | Displacement of [125I]MCH from human recombinant MCHR1 expressed CHO-K1 cell membrane by SPA-YSI assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.