Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0246 | 0.2564 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0138 | 0.11 | 0.3309 |
Trypanosoma brucei | unspecified product | 0.0153 | 0.1305 | 0.1174 |
Schistosoma mansoni | adenosine kinase | 0.0084 | 0.0376 | 0.0376 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0153 | 0.1305 | 0.1174 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0138 | 0.11 | 0.5 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0246 | 0.2564 | 0.5 |
Brugia malayi | RNase H family protein | 0.0138 | 0.11 | 0.0752 |
Toxoplasma gondii | ribonuclease HI protein | 0.0138 | 0.11 | 0.0752 |
Schistosoma mansoni | hypothetical protein | 0.0668 | 0.8291 | 0.8291 |
Echinococcus granulosus | ribonuclease H1 | 0.0138 | 0.11 | 0.0752 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0153 | 0.1305 | 0.1174 |
Brugia malayi | RNase H family protein | 0.0138 | 0.11 | 0.0752 |
Trypanosoma brucei | ribonuclease H1 | 0.0138 | 0.11 | 0.0915 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0246 | 0.2564 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0573 | 0.6998 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0246 | 0.2564 | 1 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0246 | 0.2564 | 0.2764 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0138 | 0.11 | 0.3309 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0246 | 0.2564 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0794 | 1 | 1 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0794 | 1 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0794 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0668 | 0.8291 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0138 | 0.11 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0794 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0138 | 0.11 | 0.0752 |
Leishmania major | ribonuclease H1, putative | 0.0138 | 0.11 | 0.3309 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0138 | 0.11 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0153 | 0.1305 | 0.1174 |
Schistosoma mansoni | phosphoglucomutase | 0.0138 | 0.11 | 0.11 |
Giardia lamblia | Ribonuclease H | 0.0138 | 0.11 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0084 | 0.0376 | 0.0376 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0794 | 1 | 0.5 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0794 | 1 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0138 | 0.11 | 0.11 |
Schistosoma mansoni | phosphoglucomutase | 0.0138 | 0.11 | 0.11 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0153 | 0.1305 | 0.1174 |
Echinococcus multilocularis | ribonuclease H1 | 0.0138 | 0.11 | 0.0752 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0246 | 0.2564 | 0.2483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | > 85 % | Inhibition of p53-induced p21 expression in human U2OS cells at 50 uM by luciferase reporter gene assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.