Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1849 | 0.7838 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0728 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.2277 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1675 | 0.6958 | 0.8878 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.03 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0901 | 0.3042 | 0.3881 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.2277 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2103 | 0.912 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0901 | 0.3042 | 0.3335 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0338 | 0.0191 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0474 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1549 | 0.6319 | 0.6929 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0474 | 0.088 | 0.088 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.1549 | 0.6319 | 0.6319 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.03 | 0 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0474 | 0.088 | 0.1122 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.088 | 0.088 |
Loa Loa (eye worm) | glutamate receptor | 0.1849 | 0.7838 | 0.7838 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.1549 | 0.6319 | 0.6319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.057 uM | Inhibition of human N-terminal 6-His tagged full length recombinant 11 beta HSD1 expressed in baculovirus assessed as conversion of cortisone to cortisol after 25 mins by HTRF assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.