Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | CDC72 | 0.0748 | 0.2123 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0748 | 0.2123 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0748 | 0.2123 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0748 | 0.2123 | 0.5 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.1699 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0748 | 0.2123 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.1699 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.1699 | 1 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0748 | 0.2123 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0748 | 0.2123 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.1699 | 1 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0748 | 0.2123 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.1553 | 0.8788 | 0.8461 |
Leishmania major | N-myristoyl transferase, putative | 0.0748 | 0.2123 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.1553 | 0.8788 | 0.8461 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0748 | 0.2123 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 40 ug ml-1 | Minimum inhibitory concentration to reduce cytopathicity by 50% in proliferation of human embryonic lung cells (HEL) | ChEMBL. | 8176708 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration required for antiviral activity to reduce Varicella Zoster virus (VZV) (Oka) induced cytopathicity in human embryonic lung cells (HEL) | ChEMBL. | 8176708 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration required for antiviral activity to reduce TK Varicella Zoster virus (VZV) (07/1) induced cytopathicity in human embryonic lung cells (HEL) | ChEMBL. | 8176708 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (Davis) induced cytopathicity in human embryonic lung cells (HEL) | ChEMBL. | 8176708 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (AD-169) induced cytopathicity in human embryonic lung cells (HEL) | ChEMBL. | 8176708 |
MIC (functional) | = 100 ug ml-1 | Minimum inhibitory concentration required for antiviral activity to reduce Respiratory syncytial virus (RSV) (Long) induced cytopathicity in human carcinoma cells (HeLa) | ChEMBL. | 8176708 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration to reduce cytopathicity by 50% in morphology of human carcinoma cells (HeLa) | ChEMBL. | 8176708 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.